Statins for Dementia Treatment

Pat & Dennis Bender Early Dementia Diagnosis & Prognosis Fund

J. Dennis Bender

Office, Home & Cell Phone: 859-391-5226

5726 La Jolla Blvd. – Suite 311

La Jolla, CA 92037-7345

&

Office - 100 Riverside Pl. - Suite 303

Covington, KY 41011-5711

We support the development of improved diagnostic methods for the early detection and diagnosis of MCI, Alzheimer’s, vascular and other dementias, their likely prognosis, and best treatment options. We focus on the development of Bayesian-based medical-decision-support systems, comparative-effectiveness research, and the better utilization of these for the above. (After incorporating in KY as a 501(c)(3) in 2002, we dissolved that entity for a simplified form of two entirely self-financed, private philanthropies utilizing a Vanguard Charitable Trust for making $100K annual-research-grants for early-dementia-detection and its correct differential-diagnosis and likely-prognosis. They will continue on, after I am long gone, either mentally or physically. Prof. Randall Bateman is the first of our fund’s research advisors, KMK Law is our legal advisor and David J. Bender is my Estate Rep. (See: https://www.alz.org/alzheimers-dementia/research_progress/earlier-diagnosis)

 This email address is being protected from spambots. You need JavaScript enabled to view it.

www.JDBender.com – EMS/eVTOL  & Educational Experimental Aviation Fund (Vanguard Charitable Trust)

www.JDBender.org – Dementia Diagnosis Fund (Vanguard Charitable Trust)

January 1, 2024

A common cholesterol medication could help to slow the symptoms of dementia, a new study suggests

“The majority of these patients experienced mental-decline at a lower-rate than those who weren't taking statin. . . Some patients with Alzheimer's-disease or mixed-dementia with indication for lipid-lowering-medication may benefit cognitively from statin-treatment; however, further research is needed to clarify the findings of sensitivity-analyses. . . The results of the study do not mean that we now have evidence that people with dementia should be treated with statins. But on the other hand, we can't see any support for not doing so.”

While indeed this requires a deeper-analysis, it is intuitively appealing and something that can be done now, as I have been doing myself for many years and it seems to have been helping with my own amnestic-MCI of mixed-etiology. Pat and I had visited the Karolinska Institute in Stockholm and it is an outstanding research institute.

I will be further exploring offering my 2024 $100,000 annual Vanguard Charitable research grant to them for extending this research, or to Prof. Oscar L. Lopez at the U. of Pittsburgh, as previously discussed.

Irish Star

Common Medicine Could Slow Alzheimer's-Disease, New Study Suggests

Story by Martha Brennan

Anew study has shown that a common cholesterol medication could help to slow the symptoms of Alzheimer's-disease. The research, which was undertaken by scientists in Sweden, suggests that statin drugs could reduce congestion in the brain that leads to cognitive decline.

Statins are used to help lower-bad-cholesterols in the blood known as low-density-lipoproteins (LDL). Using data from the Swedish Registry for Cognitive/Dementia Disorders, the researchers the effects of statins on pathways in the brain.

Protein pieces called beta-amyloid clump together and build-up into plaque in the pathways of brains with dementia according to the Alzheimer's Association, which reduces cognitive ability. Over three years, the researchers in Sweden looked at over 11,000 cases of people who were diagnosed with both dementia and heart-issues that required them to take statin-drugs.

They found that those that the majority of these patients experiencedmental-declineat a lower-rate than those who weren't taking statin, but the authors said another study was needed.

Sara Garcia-Ptacek, an Associate Professor of Neuroscience at the Karolinska Institute in Stockholm, said: "The results of the study do not mean that we now have evidence that people withdementiashould be treated with statins. But on the other hand, we can't see any support for not doing so. So, if a person needs statins for high-blood-lipids, a dementia-diagnosis should not stop the treatment."

Garcia-Ptacek added that a study looking at new data was needed, rather than just relying on the past data her team looked at. The authors of the study said: "Some patients withAlzheimer's-diseaseor mixed-dementiawith indication for lipid-lowering-medication may benefit cognitively from statin-treatment; however, further research is needed to clarify the findings of sensitivity-analyses."

Sara Garcia Ptacek

Assistant Professor, Docent

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Visiting address: Blickagången 16, 14152 Huddinge

Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Klinisk geriatrik Eriksdotter, 171 77 Stockholm

{Statins for Dementia Treatment}